A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
Identifieur interne : 000164 ( France/Analysis ); précédent : 000163; suivant : 000165A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
Auteurs : Yaping Shou [États-Unis] ; Douglas M. Robinson [États-Unis] ; Dereck D. Amakye [États-Unis] ; Kristine L. Rose [États-Unis] ; Yoon-Jae Cho [États-Unis] ; Keith L. Ligon [États-Unis] ; Thad Sharp [États-Unis] ; Asifa S. Haider [États-Unis] ; Raj Bandaru [États-Unis] ; Yuichi Ando [Japon] ; Birgit Geoerger [France] ; François Doz [France] ; David M. Ashley [Australie] ; Darren R. Hargrave [Royaume-Uni] ; Michela Casanova [Italie] ; Hussein A. Tawbi [États-Unis] ; Jordi Rodon [Espagne] ; Anne L. Thomas [Royaume-Uni] ; Alain C. Mita [États-Unis] ; Tobey J. Macdonald [Géorgie (pays)] ; Mark W. Kieran [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2015.
Descripteurs français
- KwdFr :
- Adolescent, Analyse de profil d'expression de gènes, Antinéoplasiques (pharmacologie), Antinéoplasiques (usage thérapeutique), Biologie informatique, Dérivés du biphényle (pharmacologie), Dérivés du biphényle (usage thérapeutique), Enfant, Enfant d'âge préscolaire, Humains, Modèles biologiques, Médulloblastome (génétique), Médulloblastome (métabolisme), Médulloblastome (traitement médicamenteux), Nourrisson, Pronostic, Protéines Hedgehog (antagonistes et inhibiteurs), Protéines Hedgehog (métabolisme), Pyridines (pharmacologie), Pyridines (usage thérapeutique), Reproductibilité des résultats, Régulation de l'expression des gènes tumoraux (), Résultat thérapeutique, Sélection de patients, Transcriptome, Transduction du signal (), Tumeurs du cervelet (génétique), Tumeurs du cervelet (métabolisme), Tumeurs du cervelet (traitement médicamenteux).
- MESH :
- antagonistes et inhibiteurs : Protéines Hedgehog.
- génétique : Médulloblastome, Tumeurs du cervelet.
- métabolisme : Médulloblastome, Protéines Hedgehog, Tumeurs du cervelet.
- pharmacologie : Antinéoplasiques, Dérivés du biphényle, Pyridines.
- traitement médicamenteux : Médulloblastome, Tumeurs du cervelet.
- usage thérapeutique : Antinéoplasiques, Dérivés du biphényle, Pyridines.
- Adolescent, Analyse de profil d'expression de gènes, Biologie informatique, Enfant, Enfant d'âge préscolaire, Humains, Modèles biologiques, Nourrisson, Pronostic, Reproductibilité des résultats, Régulation de l'expression des gènes tumoraux, Résultat thérapeutique, Sélection de patients, Transcriptome, Transduction du signal.
English descriptors
- KwdEn :
- Adolescent, Antineoplastic Agents (pharmacology), Antineoplastic Agents (therapeutic use), Biphenyl Compounds (pharmacology), Biphenyl Compounds (therapeutic use), Cerebellar Neoplasms (drug therapy), Cerebellar Neoplasms (genetics), Cerebellar Neoplasms (metabolism), Child, Child, Preschool, Computational Biology, Gene Expression Profiling, Gene Expression Regulation, Neoplastic (drug effects), Hedgehog Proteins (antagonists & inhibitors), Hedgehog Proteins (metabolism), Humans, Infant, Medulloblastoma (drug therapy), Medulloblastoma (genetics), Medulloblastoma (metabolism), Models, Biological, Patient Selection, Prognosis, Pyridines (pharmacology), Pyridines (therapeutic use), Reproducibility of Results, Signal Transduction (drug effects), Transcriptome, Treatment Outcome.
- MESH :
- chemical , antagonists & inhibitors : Hedgehog Proteins.
- chemical , metabolism : Hedgehog Proteins.
- chemical , pharmacology : Antineoplastic Agents, Biphenyl Compounds, Pyridines.
- chemical , therapeutic use : Antineoplastic Agents, Biphenyl Compounds, Pyridines.
- drug effects : Gene Expression Regulation, Neoplastic, Signal Transduction.
- drug therapy : Cerebellar Neoplasms, Medulloblastoma.
- genetics : Cerebellar Neoplasms, Medulloblastoma.
- metabolism : Cerebellar Neoplasms, Medulloblastoma.
- Adolescent, Child, Child, Preschool, Computational Biology, Gene Expression Profiling, Humans, Infant, Models, Biological, Patient Selection, Prognosis, Reproducibility of Results, Transcriptome, Treatment Outcome.
Abstract
Distinct molecular subgroups of medulloblastoma, including hedgehog (Hh) pathway-activated disease, have been reported. We identified and clinically validated a five-gene Hh signature assay that can be used to preselect patients with Hh pathway-activated medulloblastoma.
DOI: 10.1158/1078-0432.CCR-13-1711
PubMed: 25473003
Affiliations:
- Australie, Espagne, France, Géorgie (pays), Italie, Japon, Royaume-Uni, États-Unis
- Angleterre, Californie, Catalogne, Grand Londres, Massachusetts, New Jersey, Pennsylvanie, Texas, Victoria (État)
- Barcelone, Londres, Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000595
- to stream PubMed, to step Curation: 000595
- to stream PubMed, to step Checkpoint: 000595
- to stream Ncbi, to step Merge: 004264
- to stream Ncbi, to step Curation: 004264
- to stream Ncbi, to step Checkpoint: 004264
- to stream Main, to step Merge: 000655
- to stream Main, to step Curation: 000655
- to stream Main, to step Exploration: 000655
- to stream France, to step Extraction: 000164
Links to Exploration step
pubmed:25473003Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.</title><author><name sortKey="Shou, Yaping" sort="Shou, Yaping" uniqKey="Shou Y" first="Yaping" last="Shou">Yaping Shou</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Robinson, Douglas M" sort="Robinson, Douglas M" uniqKey="Robinson D" first="Douglas M" last="Robinson">Douglas M. Robinson</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Amakye, Dereck D" sort="Amakye, Dereck D" uniqKey="Amakye D" first="Dereck D" last="Amakye">Dereck D. Amakye</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Rose, Kristine L" sort="Rose, Kristine L" uniqKey="Rose K" first="Kristine L" last="Rose">Kristine L. Rose</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Cho, Yoon Jae" sort="Cho, Yoon Jae" uniqKey="Cho Y" first="Yoon-Jae" last="Cho">Yoon-Jae Cho</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Ligon, Keith L" sort="Ligon, Keith L" uniqKey="Ligon K" first="Keith L" last="Ligon">Keith L. Ligon</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Pathology, Children's Hospital Boston, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Pathology, Children's Hospital Boston, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sharp, Thad" sort="Sharp, Thad" uniqKey="Sharp T" first="Thad" last="Sharp">Thad Sharp</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Haider, Asifa S" sort="Haider, Asifa S" uniqKey="Haider A" first="Asifa S" last="Haider">Asifa S. Haider</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Bandaru, Raj" sort="Bandaru, Raj" uniqKey="Bandaru R" first="Raj" last="Bandaru">Raj Bandaru</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ando, Yuichi" sort="Ando, Yuichi" uniqKey="Ando Y" first="Yuichi" last="Ando">Yuichi Ando</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya University Hospital, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya University Hospital, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name><affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, University Paris-Sud, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, University Paris-Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Doz, Francois" sort="Doz, Francois" uniqKey="Doz F" first="François" last="Doz">François Doz</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie and University Paris Descartes, Sorbonne Paris Cité, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie and University Paris Descartes, Sorbonne Paris Cité</wicri:regionArea><wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion><wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion></affiliation></author><author><name sortKey="Ashley, David M" sort="Ashley, David M" uniqKey="Ashley D" first="David M" last="Ashley">David M. Ashley</name><affiliation wicri:level="3"><nlm:affiliation>Deakin University/Barwon Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Deakin University/Barwon Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hargrave, Darren R" sort="Hargrave, Darren R" uniqKey="Hargrave D" first="Darren R" last="Hargrave">Darren R. Hargrave</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Hospital for Children, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Great Ormond Street Hospital for Children</wicri:orgArea></affiliation></author><author><name sortKey="Casanova, Michela" sort="Casanova, Michela" uniqKey="Casanova M" first="Michela" last="Casanova">Michela Casanova</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Tawbi, Hussein A" sort="Tawbi, Hussein A" uniqKey="Tawbi H" first="Hussein A" last="Tawbi">Hussein A. Tawbi</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Cancer Institute and University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Rodon, Jordi" sort="Rodon, Jordi" uniqKey="Rodon J" first="Jordi" last="Rodon">Jordi Rodon</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron Institut d'Oncologia, and Universitat Autonoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron Institut d'Oncologia, and Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Thomas, Anne L" sort="Thomas, Anne L" uniqKey="Thomas A" first="Anne L" last="Thomas">Anne L. Thomas</name><affiliation wicri:level="1"><nlm:affiliation>University of Leicester, Leicester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Mita, Alain C" sort="Mita, Alain C" uniqKey="Mita A" first="Alain C" last="Mita">Alain C. Mita</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Macdonald, Tobey J" sort="Macdonald, Tobey J" uniqKey="Macdonald T" first="Tobey J" last="Macdonald">Tobey J. Macdonald</name><affiliation wicri:level="1"><nlm:affiliation>Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Kieran, Mark W" sort="Kieran, Mark W" uniqKey="Kieran M" first="Mark W" last="Kieran">Mark W. Kieran</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. mark_kieran@dfci.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25473003</idno><idno type="pmid">25473003</idno><idno type="doi">10.1158/1078-0432.CCR-13-1711</idno><idno type="wicri:Area/PubMed/Corpus">000595</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000595</idno><idno type="wicri:Area/PubMed/Curation">000595</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000595</idno><idno type="wicri:Area/PubMed/Checkpoint">000595</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000595</idno><idno type="wicri:Area/Ncbi/Merge">004264</idno><idno type="wicri:Area/Ncbi/Curation">004264</idno><idno type="wicri:Area/Ncbi/Checkpoint">004264</idno><idno type="wicri:doubleKey">1078-0432:2015:Shou Y:a:five:gene</idno><idno type="wicri:Area/Main/Merge">000655</idno><idno type="wicri:Area/Main/Curation">000655</idno><idno type="wicri:Area/Main/Exploration">000655</idno><idno type="wicri:Area/France/Extraction">000164</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.</title><author><name sortKey="Shou, Yaping" sort="Shou, Yaping" uniqKey="Shou Y" first="Yaping" last="Shou">Yaping Shou</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Robinson, Douglas M" sort="Robinson, Douglas M" uniqKey="Robinson D" first="Douglas M" last="Robinson">Douglas M. Robinson</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Amakye, Dereck D" sort="Amakye, Dereck D" uniqKey="Amakye D" first="Dereck D" last="Amakye">Dereck D. Amakye</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Rose, Kristine L" sort="Rose, Kristine L" uniqKey="Rose K" first="Kristine L" last="Rose">Kristine L. Rose</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Cho, Yoon Jae" sort="Cho, Yoon Jae" uniqKey="Cho Y" first="Yoon-Jae" last="Cho">Yoon-Jae Cho</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Departments of Neurology and Neurosurgery, Stanford University School of Medicine, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Ligon, Keith L" sort="Ligon, Keith L" uniqKey="Ligon K" first="Keith L" last="Ligon">Keith L. Ligon</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Pathology, Children's Hospital Boston, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Pathology, Children's Hospital Boston, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts. Department of Medical Oncology and Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Sharp, Thad" sort="Sharp, Thad" uniqKey="Sharp T" first="Thad" last="Sharp">Thad Sharp</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Haider, Asifa S" sort="Haider, Asifa S" uniqKey="Haider A" first="Asifa S" last="Haider">Asifa S. Haider</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Novartis Pharmaceuticals Corporation, East Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Bandaru, Raj" sort="Bandaru, Raj" uniqKey="Bandaru R" first="Raj" last="Bandaru">Raj Bandaru</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Novartis Institutes for BioMedical Research, Inc, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Ando, Yuichi" sort="Ando, Yuichi" uniqKey="Ando Y" first="Yuichi" last="Ando">Yuichi Ando</name><affiliation wicri:level="1"><nlm:affiliation>Nagoya University Hospital, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Nagoya University Hospital, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name><affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, University Paris-Sud, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Gustave Roussy, University Paris-Sud, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Doz, Francois" sort="Doz, Francois" uniqKey="Doz F" first="François" last="Doz">François Doz</name><affiliation wicri:level="1"><nlm:affiliation>Institut Curie and University Paris Descartes, Sorbonne Paris Cité, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie and University Paris Descartes, Sorbonne Paris Cité</wicri:regionArea><wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion><wicri:noRegion>Sorbonne Paris Cité</wicri:noRegion></affiliation></author><author><name sortKey="Ashley, David M" sort="Ashley, David M" uniqKey="Ashley D" first="David M" last="Ashley">David M. Ashley</name><affiliation wicri:level="3"><nlm:affiliation>Deakin University/Barwon Health, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Deakin University/Barwon Health, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Hargrave, Darren R" sort="Hargrave, Darren R" uniqKey="Hargrave D" first="Darren R" last="Hargrave">Darren R. Hargrave</name><affiliation wicri:level="3"><nlm:affiliation>Great Ormond Street Hospital for Children, London.</nlm:affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><wicri:orgArea>Great Ormond Street Hospital for Children</wicri:orgArea></affiliation></author><author><name sortKey="Casanova, Michela" sort="Casanova, Michela" uniqKey="Casanova M" first="Michela" last="Casanova">Michela Casanova</name><affiliation wicri:level="1"><nlm:affiliation>Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Fondazione IRCCS Istituto Nazionale dei Tumori, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Tawbi, Hussein A" sort="Tawbi, Hussein A" uniqKey="Tawbi H" first="Hussein A" last="Tawbi">Hussein A. Tawbi</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Cancer Institute and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Cancer Institute and University of Pittsburgh School of Medicine, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Rodon, Jordi" sort="Rodon, Jordi" uniqKey="Rodon J" first="Jordi" last="Rodon">Jordi Rodon</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron Institut d'Oncologia, and Universitat Autonoma de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron Institut d'Oncologia, and Universitat Autonoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Thomas, Anne L" sort="Thomas, Anne L" uniqKey="Thomas A" first="Anne L" last="Thomas">Anne L. Thomas</name><affiliation wicri:level="1"><nlm:affiliation>University of Leicester, Leicester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Mita, Alain C" sort="Mita, Alain C" uniqKey="Mita A" first="Alain C" last="Mita">Alain C. Mita</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Cancer Therapy and Research Center, University of Texas Health Science Center, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Macdonald, Tobey J" sort="Macdonald, Tobey J" uniqKey="Macdonald T" first="Tobey J" last="Macdonald">Tobey J. Macdonald</name><affiliation wicri:level="1"><nlm:affiliation>Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Children's Healthcare of Atlanta, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Kieran, Mark W" sort="Kieran, Mark W" uniqKey="Kieran M" first="Mark W" last="Kieran">Mark W. Kieran</name><affiliation wicri:level="2"><nlm:affiliation>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts. mark_kieran@dfci.harvard.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Pediatric Neuro-Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Antineoplastic Agents (pharmacology)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Biphenyl Compounds (pharmacology)</term><term>Biphenyl Compounds (therapeutic use)</term><term>Cerebellar Neoplasms (drug therapy)</term><term>Cerebellar Neoplasms (genetics)</term><term>Cerebellar Neoplasms (metabolism)</term><term>Child</term><term>Child, Preschool</term><term>Computational Biology</term><term>Gene Expression Profiling</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Hedgehog Proteins (antagonists & inhibitors)</term><term>Hedgehog Proteins (metabolism)</term><term>Humans</term><term>Infant</term><term>Medulloblastoma (drug therapy)</term><term>Medulloblastoma (genetics)</term><term>Medulloblastoma (metabolism)</term><term>Models, Biological</term><term>Patient Selection</term><term>Prognosis</term><term>Pyridines (pharmacology)</term><term>Pyridines (therapeutic use)</term><term>Reproducibility of Results</term><term>Signal Transduction (drug effects)</term><term>Transcriptome</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Analyse de profil d'expression de gènes</term><term>Antinéoplasiques (pharmacologie)</term><term>Antinéoplasiques (usage thérapeutique)</term><term>Biologie informatique</term><term>Dérivés du biphényle (pharmacologie)</term><term>Dérivés du biphényle (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Modèles biologiques</term><term>Médulloblastome (génétique)</term><term>Médulloblastome (métabolisme)</term><term>Médulloblastome (traitement médicamenteux)</term><term>Nourrisson</term><term>Pronostic</term><term>Protéines Hedgehog (antagonistes et inhibiteurs)</term><term>Protéines Hedgehog (métabolisme)</term><term>Pyridines (pharmacologie)</term><term>Pyridines (usage thérapeutique)</term><term>Reproductibilité des résultats</term><term>Régulation de l'expression des gènes tumoraux ()</term><term>Résultat thérapeutique</term><term>Sélection de patients</term><term>Transcriptome</term><term>Transduction du signal ()</term><term>Tumeurs du cervelet (génétique)</term><term>Tumeurs du cervelet (métabolisme)</term><term>Tumeurs du cervelet (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Hedgehog Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hedgehog Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Biphenyl Compounds</term><term>Pyridines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term><term>Biphenyl Compounds</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines Hedgehog</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation, Neoplastic</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cerebellar Neoplasms</term><term>Medulloblastoma</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cerebellar Neoplasms</term><term>Medulloblastoma</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Médulloblastome</term><term>Tumeurs du cervelet</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebellar Neoplasms</term><term>Medulloblastoma</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Médulloblastome</term><term>Protéines Hedgehog</term><term>Tumeurs du cervelet</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Dérivés du biphényle</term><term>Pyridines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Médulloblastome</term><term>Tumeurs du cervelet</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term><term>Dérivés du biphényle</term><term>Pyridines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Computational Biology</term><term>Gene Expression Profiling</term><term>Humans</term><term>Infant</term><term>Models, Biological</term><term>Patient Selection</term><term>Prognosis</term><term>Reproducibility of Results</term><term>Transcriptome</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Analyse de profil d'expression de gènes</term><term>Biologie informatique</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Humains</term><term>Modèles biologiques</term><term>Nourrisson</term><term>Pronostic</term><term>Reproductibilité des résultats</term><term>Régulation de l'expression des gènes tumoraux</term><term>Résultat thérapeutique</term><term>Sélection de patients</term><term>Transcriptome</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Distinct molecular subgroups of medulloblastoma, including hedgehog (Hh) pathway-activated disease, have been reported. We identified and clinically validated a five-gene Hh signature assay that can be used to preselect patients with Hh pathway-activated medulloblastoma.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li><li>Géorgie (pays)</li><li>Italie</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Catalogne</li><li>Grand Londres</li><li>Massachusetts</li><li>New Jersey</li><li>Pennsylvanie</li><li>Texas</li><li>Victoria (État)</li></region><settlement><li>Barcelone</li><li>Londres</li><li>Melbourne</li></settlement></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Shou, Yaping" sort="Shou, Yaping" uniqKey="Shou Y" first="Yaping" last="Shou">Yaping Shou</name></region><name sortKey="Amakye, Dereck D" sort="Amakye, Dereck D" uniqKey="Amakye D" first="Dereck D" last="Amakye">Dereck D. Amakye</name><name sortKey="Bandaru, Raj" sort="Bandaru, Raj" uniqKey="Bandaru R" first="Raj" last="Bandaru">Raj Bandaru</name><name sortKey="Cho, Yoon Jae" sort="Cho, Yoon Jae" uniqKey="Cho Y" first="Yoon-Jae" last="Cho">Yoon-Jae Cho</name><name sortKey="Haider, Asifa S" sort="Haider, Asifa S" uniqKey="Haider A" first="Asifa S" last="Haider">Asifa S. Haider</name><name sortKey="Kieran, Mark W" sort="Kieran, Mark W" uniqKey="Kieran M" first="Mark W" last="Kieran">Mark W. Kieran</name><name sortKey="Ligon, Keith L" sort="Ligon, Keith L" uniqKey="Ligon K" first="Keith L" last="Ligon">Keith L. Ligon</name><name sortKey="Mita, Alain C" sort="Mita, Alain C" uniqKey="Mita A" first="Alain C" last="Mita">Alain C. Mita</name><name sortKey="Robinson, Douglas M" sort="Robinson, Douglas M" uniqKey="Robinson D" first="Douglas M" last="Robinson">Douglas M. Robinson</name><name sortKey="Rose, Kristine L" sort="Rose, Kristine L" uniqKey="Rose K" first="Kristine L" last="Rose">Kristine L. Rose</name><name sortKey="Sharp, Thad" sort="Sharp, Thad" uniqKey="Sharp T" first="Thad" last="Sharp">Thad Sharp</name><name sortKey="Tawbi, Hussein A" sort="Tawbi, Hussein A" uniqKey="Tawbi H" first="Hussein A" last="Tawbi">Hussein A. Tawbi</name></country><country name="Japon"><noRegion><name sortKey="Ando, Yuichi" sort="Ando, Yuichi" uniqKey="Ando Y" first="Yuichi" last="Ando">Yuichi Ando</name></noRegion></country><country name="France"><noRegion><name sortKey="Geoerger, Birgit" sort="Geoerger, Birgit" uniqKey="Geoerger B" first="Birgit" last="Geoerger">Birgit Geoerger</name></noRegion><name sortKey="Doz, Francois" sort="Doz, Francois" uniqKey="Doz F" first="François" last="Doz">François Doz</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Ashley, David M" sort="Ashley, David M" uniqKey="Ashley D" first="David M" last="Ashley">David M. Ashley</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hargrave, Darren R" sort="Hargrave, Darren R" uniqKey="Hargrave D" first="Darren R" last="Hargrave">Darren R. Hargrave</name></region><name sortKey="Thomas, Anne L" sort="Thomas, Anne L" uniqKey="Thomas A" first="Anne L" last="Thomas">Anne L. Thomas</name></country><country name="Italie"><noRegion><name sortKey="Casanova, Michela" sort="Casanova, Michela" uniqKey="Casanova M" first="Michela" last="Casanova">Michela Casanova</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Rodon, Jordi" sort="Rodon, Jordi" uniqKey="Rodon J" first="Jordi" last="Rodon">Jordi Rodon</name></region></country><country name="Géorgie (pays)"><noRegion><name sortKey="Macdonald, Tobey J" sort="Macdonald, Tobey J" uniqKey="Macdonald T" first="Tobey J" last="Macdonald">Tobey J. Macdonald</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000164 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000164 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:25473003
|texte= A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:25473003" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |